The Ecoflac® plus IV container is made of a medical grade Polyethylene (PE) material which is chemically inert and toxicologically safe. It is free from PVC and DEHP and thus provides compatibility with a large number of pharmaceuticals, in order to help reduce the risk of drug incompatibilities and to prevent patients from DEHP exposure. Our ConComp database provides compatibility information between IV drugs, containers materials and IV solutions.
PVC-free
A number of drugs are known to interact with PVC and adhere to it [1]. Because of this sorption effect, IV containers made with PVC can have negative effects on IV medication delivery and may compromise the patient receiving the correct amount of IV medication[1].
Ecoflac® plus is free of PVC, in order to avoid dosage errors caused by possible interactions between the drug and the container material.
DEHP-free
DEHP can leach out of the PVC material of the container into the solutions, when in contact with certain drugs[1]. The exposure to DEHP can have significant health consequences for patients [2] [3]. Ecoflac® plus is free of DEHP as well as other additives and compounds that may potentially migrate into the finished preparation.
ConComp database
ConComp is a comprehensive information source for all your compatibility questions on IV drugs, containers materials and IV solutions. The database is accessible for free to all registered medical professionals. All data is supplied as abstracts taken from hundreds of original publications and internal research.
For more details visit our website at: www.concomp-partner.com
[1] Lawrence A. Trissel. Handbook on Injectable Drugs, 17th edition
[2] Sjoberg P, Bondesson U, Gray TJB and Ploen L. (1986) Effects of Di(2-ehtylhexyl) Phthalate and Five of its Metabolites on Rat Tests in Vivo and in Vitro. Acta pharmacol et toxicol 58: 225-233.
[3] European Commission Health & Consumer Protection Directorate General (2002) OPINION ON: Medical Devices Containing DEHP Plasticised PVC; Neonates and Other Groups Possibly at Risk from DEHP; Toxicity. European Commission. pp 1-34